Calprotectin in Lung Diseases

Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins, S100A8 and S100A9. It multifunctional protein expressed mainly neutrophils released extracellularly activated or damaged cells mediating broad range of physiological pathological responses. has been more than 20 years since the implication S100A8/A9 in inflammatory process was shown; however, evaluation its role pathogenesis respiratory diseases usefulness as biomarker for appropriate diagnosis prognosis lung have only gained attention recent years. This review aimed to provide current knowledge regarding potential CLP pathophysiology describe how this is, up until now, translated into daily clinical practice. involved numerous cellular processes health disease. In addition anti-microbial functions, also serves molecule with pro- anti-tumor properties related cell survival growth, angiogenesis, DNA damage response, remodeling extracellular matrix. The findings potentially introduce practice within spectrum diseases.